AMPro Publications


Silke Rath, Tatjana Rud, André Karch, Dietmar Helmut Pieper and Marius Vital. Pathogenic functions of host microbiota. Microbiome. 2018.

Stefan Dehmel, Petra Nathan, Sabine Bartel, Natalia El-Merhie, Hagen Scherb, Katrin Milger, Gerrit John-Schuster, Ali Oender Yildirim, Machteld Hylkema, Martin Irmler, Johannes Beckers, Bianca Schaub, Oliver Eickelberg, Susanne Krauss-Etschmann. Intrauterine smoke exposure deregulates lung function, pulmonary transcriptomes, and in particular insulin-like growth factor (IGF)-1 in a sex-specific manner. Scientific Reports. 2018.

Lena Wischhof, Anna Gioran, Dagmar Sonntag-Bensch, Antonia Piazzesi, Miriam Stork, Pierluigi Nicotera, Daniele Bano. A disease-associated Aifm1 variant induces severe myopathy in knockin mice. Molecular Metabolism. 2018.

Daniele Bano, Jochen H. M. Prehn. Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer. EBioMedicine. 2018.

Alexandra Moraru, Janica Wiederstein, Daniel Pfaff, Thomas Fleming, Aubry K. Miller, Peter Nawroth, Aurelio A. Teleman. Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes. Cell Metabolism. 2018.

Kan Xie, Devon P. Ryan, Brandon L. Pearson, Kristin S. Henzel, Frauke Neff, Ramon O. Vidal, Magali Hennion, Isabelle Lehmann, Melvin Schleif, Susanne Schröder, Thure Adler, Birgit Rathkolb, Jan Rozman, Anna-Lena Schütz, Cornelia Prehn, Michel E. Mickael, Marco Weiergräber, Jerzy Adamski, Dirk H. Busch, Gerhard Ehninger, Anna Matynia, Walker S. Jackson, Eckhard Wolf, Helmut Fuchs, Valerie Gailus-Durner, Stefan Bonn, Martin Hrabe de Angelis, Dan Ehninger. Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice. Proc Natl Acad Sci U S A. 2018.

Xianming Wang, Michael Sterr, Ingo Burtscher, Shen Chen, Anja Hieronimus, Fausto Machicao, Harald Staiger, Hans-Ulrich Häring, Gabriele Lederer, Thomas Meitinger, Filippo M. Cernilogar, Gunnar Schotta, Martin Irmler, Johannes Beckers, Martin Hrabě de Angelis, Michael Ray, Christopher V.E. Wright, Mostafa Bakhti, Heiko Lickert. Genome-wide analysis of PDX1 target genes in human pancreatic progenitors. Molecular Metabolism. 2018.


Marius Vital, André Karch, Dietmar H. Pieper. Colonic Butyrate-Producing Communities in Humans: an Overview Using Omics Data. mSystems. 2017.

Topic related publications

proposed by the consortium


Garcia-Prat, L. and P. Munoz-Canoves, Aging, metabolism and stem cells: Spotlight on muscle stem cells. Mol Cell Endocrinol, 2017. 445: p. 109-117.

Lushchak, O., et al., The role of the TOR pathway in mediating the link between nutrition and longevity. Mech Ageing Dev, 2017.

Man, K., V.I. Kutyavin, and A. Chawla, Tissue Immunometabolism: Development, Physiology, and Pathobiology. Cell Metab, 2017. 25(1): p. 11-26.

Sharma, U. and O.J. Rando, Metabolic Inputs into the Epigenome. Cell Metab, 2017. 25(3): p. 544-558.

Stout, M.B., et al., Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty. Physiology (Bethesda), 2017. 32(1): p. 9-19.

Vaiserman, A.M., A.K. Koliada, and F. Marotta, Gut microbiota: A player in aging and a target for anti-aging intervention. Ageing Res Rev, 2017. 35: p. 36-45.  



Bonner-Weir, S. and C. Aguayo-Mazzucato, Physiology: Pancreatic beta-cell heterogeneity revisited. Nature, 2016. 535(7612): p. 365-6. 

Gruber, J., Z. Yee, and N.S. Tolwinski, Developmental Drift and the Role of Wnt Signaling in Aging. Cancers (Basel), 2016. 8(8).

Holmes, D., Diabetes: beta-cell heterogeneity - key to unlocking islet regeneration. Nat Rev Endocrinol, 2016. 12(9): p. 495.

Kapahi, P., M. Kaeberlein, and M. Hansen, Dietary restriction and lifespan: Lessons from invertebrate models. Ageing Res Rev, 2016.

Peleg, S., et al., The Metabolic Impact on Histone Acetylation and Transcription in Ageing. Trends Biochem Sci, 2016. 41(8): p. 700-11.  



Fleming, T. and P.P. Nawroth, Reactive metabolites as a cause of late diabetic complications. Biochem Soc Trans, 2014. 42(2): p. 439-42.   014. 63(10): p. 1238-49. 

Marg, A., et al., Human satellite cells have regenerative capacity and are genetically manipulable. J Clin Invest, 2014. 124(10): p. 4257-65.

Longo, V.D. and M.P. Mattson, Fasting: molecular mechanisms and clinical applications. Cell Metab, 2014. 19(2): p. 181-92.

Solon-Biet, S.M., et al., The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. Cell Metab, 2014. 19(3): p. 418-30.



Ribaric, S., Diet and aging. Oxid Med Cell Longev, 2012. 2012: p. 741468.

Liu, H., et al., Augmented Wnt signaling in a mammalian model of accelerated aging. Science, 2007. 317(5839): p. 803-6. 

published by the members of the consortium


Beyer, M. and J. Huehn, Epigenetic orchestration of thymic Treg cell development. Nat Immunol, 2017. 18(2): p. 144-146.



Bader, E., et al., Identification of proliferative and mature beta-cells in the islets of Langerhans. Nature, 2016. 535(7612): p. 430-4.

Roscioni, S.S., et al., Impact of islet architecture on beta-cell heterogeneity, plasticity and function. Nat Rev Endocrinol, 2016. 12(12): p. 695-709.

Tas, J.M., et al., Visualizing antibody affinity maturation in germinal centers. Science, 2016. 351(6277): p. 1048-54.

Schmidt, V., et al., SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity. J Clin Invest, 2016. 126(7): p. 2706-20.



von Eyss, B., et al., A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer. Cancer Cell, 2015. 28(6): p. 743-57.

Zhang, J., et al., A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice. Neurobiol Dis, 2015. 82: p. 32-45.



Diaz, M.B., S. Herzig, and A. Vegiopoulos, Thermogenic adipocytes: from cells to physiology and medicine. Metabolism, 2

Caglayan, S., et al., Lysosomal sorting of amyloid-beta by the SORLA receptor is impaired by a familial Alzheimer's disease mutation. Sci Transl Med, 2014. 6(223): p. 223ra20.

Pietzke, M. and S. Kempa, Pulsed stable isotope-resolved metabolomic studies of cancer cells. Methods Enzymol, 2014. 543: p. 179-98. 

Pietzke, M., et al., Decoding the dynamics of cellular metabolism and the action of 3-bromopyruvate and 2-deoxyglucose using pulsed stable isotope-resolved metabolomics. Cancer Metab, 2014. 2: p. 9. 



Dorr, J.R., et al., Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. Nature, 2013. 501(7467): p. 421-5.

Seib, D.R., et al., Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline. Cell Stem Cell, 2013. 12(2): p. 204-14.



Brohl, D., et al., Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on Notch signals. Dev Cell, 2012. 23(3): p. 469-81.

Liu, L., et al., Deregulated MYC expression induces dependence upon AMPK-related kinase 5. Nature, 2012. 483(7391): p. 608-12.

Schmidt, V., et al., Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease. EMBO J, 2012. 31(1): p. 187-200. 

Kjolby, M., et al., Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export. Cell Metab, 2010. 12(3): p. 213-23.

Nogueiras, R., et al., Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability. Endocrinology, 2008. 149(6): p. 3009-15.

Sakkou, M., et al., A role for brain-specific homeobox factor Bsx in the control of hyperphagia and locomotory behavior. Cell Metab, 2007. 5(6): p. 450-63.

Vasyutina, E., et al., RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells. Proc Natl Acad Sci U S A, 2007. 104(11): p. 4443-8. 

Willnow, T.E., C.M. Petersen, and A. Nykjaer, VPS10P-domain receptors - regulators of neuronal viability and function. Nat Rev Neurosci, 2008. 9(12): p.899-909.


Dr. Claudia Prothmann

Dr. Sabine Rehberger-Schneider

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