AMPro in brief
All centers of the Helmholtz Health Research Section are working together with the aim of exploring innovative prevention and treatment approaches to age-related diseases. More...
AMPro - Aging and Metabolic Programming
Most chronic diseases such as diabetes, cancer, cardiovascular, respiratory and neurodegenerative diseases as well as chronic infections increase in incidence with age. This indicates common age-related mechanisms acting jointly. Due to increasing life expectancy throughout the world, those age-related diseases are emerging as a growing challenge for patients, doctors, the healthcare system and society as a whole.
Among other things, the AMPro consortium is seeking out new preventive and therapeutic approaches that have a positive effect on metabolic processes. This should enable the innovative and consistent treatment of age-related diseases. The following key aspects of metabolic processes associated with aging will be investigated.
Metabolic pre- and reprogramming
Prenatal and postnatal mechanisms of metabolic programming at the genetic and epigenetic levels
Mechanisms of organ and tissue communication
Stem cell function and tissue maintenance
Tissue and cellular repair mechanisms
The long-term goal is to improve health in an aging society. AMPro creates ideal conditions for successfully tackling one of the most pressing issues in today's society and meeting the challenges of age-related diseases.
Georgios Kalamakis et al.
Quiescence modulates stem cell maintenance and regenerative capacity in the aging brain.
Cell. March 2019.
Anna Gioran et al.
Xanthine derivatives promote survival of mitochondrial deficient animals.
The EMBO Journal. February 2019.
Please find here links to the PubMed search for related topics.
Contact - Project Management
Dr. Claudia Prothmann
Institute for Diabetes and Cancer IDC
Helmholtz Center Munich (HMGU)
Ingolstädter Landstraße 1
Phone: +49 89 3187-49394
Dr. Sabine Rehberger-Schneider
Division of Signal Transduction in Cancer and Metabolism
German Cancer Research Center (DKFZ) - B140
Im Neuenheimer Feld 580
Phone: +49 6221 42-1628